UIC Researcher of the Year 2018 held a seminar at UTMN

Education 26 June 2019
Professor Yury Polikanov, honoured as a Researcher of the Year in 2018 at the University of Illinois in Chicago (US) (2018 Researcher of the Year Yury Polikanov | UIC Today), held a seminar "From the ribosome structure and function to treating an infection with antibiotics" at UTMN on June 17.

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Over the past 70 years, antibiotics have saved millions of lives. However, antibiotics are used too widely and irrationally that microorganisms have developed resistance to many of them. As a result, we need to develop new antibiotics constantly to replace those which pathogens are already resistant to. Antimicrobial resistance is one of the most important challenges humanity face.

“More than half of all anti-infective drugs used in clinics are chemicals that block the work of ribosomes in bacteria cells. The ribosome is a huge molecular machine responsible for the synthesis of proteins. There are thousands of ribosomes in every cell of every living being. They differ slightly in various organisms, allowing antibiotics to selectively inhibit the activity of bacterial ribosomes only having no effect on human ones. Since the first structure of the ribosome was obtained by X-ray structural analysis, this method has been actively used to visualize antibiotics associated with the ribosome and allows them to improve their quality rationally.

Search and study of new antibiotics properties affecting translation in ribosomes are the subject of Yuri Polikanov’s research. In cooperation with Alexey Vasilchenko’s research team, engaged in the search for antimicrobial peptides, Polikanov is studying the mechanisms of blocking translation on ribosomes. Researches use a synchrotron radiation source at the Argonne National Laboratory in Chicago and the newest cryoelectron microscope (CryoEM)".

Starting in September 2019, Prof. Polikanov will conduct a course in Biochemistry in English for undergraduates at the Institute of Environmental and Agricultural Biology (X-BIO).

Source: UTMN Department of Strategic Communications 

Link to Russian version: https://www.utmn.ru/presse/novosti/x-bio/731990/

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